Meydan LabSystems & Computational Biomedicine · Weill Cornell Medicine

Integrative multi-omics and machine learning to understand disease, immunity, and human adaptation

We build computational models that combine genomics, epigenomics, and transcriptomics to reveal the molecular drivers of hematologic disease, inflammation, and the biology of spaceflight.

Research

The Meydan Lab develops computational and machine-learning approaches for integrative analysis of large-scale molecular data. Working closely with experimental and clinical collaborators across Weill Cornell Medicine and beyond, we study how genetic, epigenetic, and environmental factors shape cell state in health and disease.

Hematologic Disease & Immunity

Epigenetic regulation and chromatin remodeling in acute myeloid leukemia and lymphoma, clonal evolution, therapy resistance, and immune reprogramming of the tumor niche.

Spaceflight & Inflammation

Multi-omic profiling of astronauts and model systems to understand how spaceflight and other inflammatory stressors, including viral infection, affect human physiology.

Microbe–Host–Environment

Metagenomic and host-response analyses that connect microbial communities and their environment to human biology and disease risk.

On the Cover

Principal Investigator

Cem Meydan, Ph.D.

Cem Meydan, Ph.D.

Assistant Professor
Computational Biology Research, Systems & Computational Biomedicine, Weill Cornell Medicine
WorldQuant Initiative for Quantitative Prediction
Meyer Cancer Center, Weill Cornell Medicine

Dr. Meydan is a computational biologist working on integrative analysis of epigenomic, genomic, and transcriptomic data using computational models and machine learning. His work spans hematologic malignancies, host response to infection, and human spaceflight, from the NASA Twins Study to the Space Omics and Medical Atlas, with more than 200 publications in journals including Nature, Science, Cell, and Cancer Cell.

Publications

200+Publications
12,000+Citations
51h-index

Selected

  1. 2024
    The Space Omics and Medical Atlas (SOMA) and international astronaut biobankOverbey EG, Kim JK, Tierney BT, Park J, …, Meydan C#, Mason CE#Nature · doi:10.1038/s41586-024-07639-y
  2. 2024
    ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesisBarisic D*, Chin CR*, Meydan C*, et al.Cancer Cell · doi:10.1016/j.ccell.2024.02.010
  3. 2024
    Molecular and physiological changes in the SpaceX Inspiration4 civilian crewJones CW, Overbey EG, Lacombe J, Ecker AJ, Meydan C, et al.Nature · doi:10.1038/s41586-024-07648-x
  4. 2022
    System-wide transcriptome damage and tissue identity loss in COVID-19 patientsPark J, Foox J, …, Meydan C#, Schwartz RE#, Mason CE#Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100522
  5. 2021
    Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformationRivas M, Meydan C, et al.Nature Immunology · doi:10.1038/s41590-020-00827-8
  6. 2021
    Shotgun transcriptome, isothermal, and spatial omics profiling of SARS-CoV-2 infectionButler D*, Mozsary C*, Meydan C*, et al.Nature Communications · doi:10.1038/s41467-021-21361-7
  7. 2020
    Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impactda Silveira WA*, …, Meydan C*, et al.Cell · doi:10.1016/j.cell.2020.11.002
  8. 2020
    Multi-omic, single-cell, and biochemical profiles of astronauts guide pharmacological strategies for returning to gravityGertz ML, Chin CR, …, Meydan C, Mason CECell Reports · doi:10.1016/j.celrep.2020.108429
  9. 2019
    The NASA Twins Study: A multidimensional analysis of a year-long human spaceflightGarrett-Bakelman FE*, …, Meydan C*, et al.Science · doi:10.1126/science.aau8650

Recent

  1. 2026
    SPEN loss drives extrafollicular diffuse large B-cell lymphoma with female-specific lethality and therapeutic vulnerabilitiesPelzer B, Meydan C, Spiegel IM, Karagiannidis I, et al.Cancer Discovery · doi:10.1158/2159-8290.CD-25-1458
  2. 2026
    Epigenetic regulation of chromosomal instability by EZH2 methyltransferaseBai Y, Agustinus AS, Yomtoubian S, Meydan C, et al.Cancer Discovery · doi:10.1158/2159-8290.CD-25-0947
  3. 2026
    Targeting macrophage ferritin heavy chain mitigates ferroptosis and lung injury in experimental acute respiratory distress syndromeZhang WZ, Kim K, Bhatia D, et al.Nature Communications · doi:10.1038/s41467-026-74828-w
  4. 2026
    CCAAT-enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemiaPrajapati SC, Meydan C, Neelamraju Y, et al.Neoplasia · doi:10.1016/j.neo.2026.101293
  5. 2026
    The LMO2-LDB1-TAL1 complex regulates transcription networks in acute myeloid leukemiaDunham N, Wang Z, Neelamraju Y, Guo Y, Paudel BB, Meydan C, et al.Blood Neoplasia · doi:10.1016/j.bneo.2025.100186
  6. 2025
    EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell functionIsshiki Y, Chen X, Teater M, et al., Meydan C, et al.Cancer Cell · doi:10.1016/j.ccell.2024.11.006
  7. 2025
    Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct myeloid diseases and molecular outcomesSakamoto T, Leca J, Zhang X, Meydan C, et al.PNAS · doi:10.1073/pnas.2415779122

* co-first author  ·  # co-corresponding author

Join Us

We welcome inquiries from postdoctoral fellows, graduate students, and research analysts with backgrounds in computational biology, machine learning, statistics, or genomics. Please email a CV and a brief statement of research interests.

Get in touch

Contact

Meydan Lab
Institute for Computational Biomedicine
Weill Cornell Medicine
1305 York Avenue, 13th Floor
New York, NY 10021

cem2009@med.cornell.edu
+1 212 746 6360